Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (from 405 mg Zinc Gluconate)
50 mg
455%
Top Medical Research Studies
9
We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.
To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.
Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).
Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.
To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.
Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).
Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.
Read More
9
We explored how zinc supplementation could help manage cholestatic liver disease, a condition that currently lacks effective treatment options. Our study involved both mice and human participants, revealing interesting changes in gut microbiome dynamics when zinc was introduced. Specifically, we noted that zinc boosts levels of a beneficial bacterium called Blautia producta, which in turn helps produce p-coumaric acid.
The fascinating part is that higher p-coumaric acid levels were linked to reduced liver injury in patients with cholestatic liver disease. In experiments with mice, we found that the protective effects of zinc were partly due to the ability of p-coumaric acid to limit harmful reactive oxygen species in liver cells. This suggests that p-coumaric acid directly supports liver health by preventing cell death and damage.
However, the benefits of zinc were less pronounced when we manipulated the production of p-coumaric acid. This implies that the relationship between zinc, gut bacteria, and liver health is quite intricate. Overall, our findings suggest that zinc may provide valuable support for individuals suffering from cholestatic liver disease, primarily through its influence on the gut microbiome and subsequent metabolic processes.
The fascinating part is that higher p-coumaric acid levels were linked to reduced liver injury in patients with cholestatic liver disease. In experiments with mice, we found that the protective effects of zinc were partly due to the ability of p-coumaric acid to limit harmful reactive oxygen species in liver cells. This suggests that p-coumaric acid directly supports liver health by preventing cell death and damage.
However, the benefits of zinc were less pronounced when we manipulated the production of p-coumaric acid. This implies that the relationship between zinc, gut bacteria, and liver health is quite intricate. Overall, our findings suggest that zinc may provide valuable support for individuals suffering from cholestatic liver disease, primarily through its influence on the gut microbiome and subsequent metabolic processes.
Read More
8
We explored the impact of zinc on liver disease by focusing on its levels in patients with decompensated liver cirrhosis. This study involved 100 individuals with advanced liver issues and another 100 healthy individuals for comparison.
Our findings revealed that serum zinc levels were significantly lower in cirrhotic patients compared to healthy controls. In fact, the levels were remarkably diminished, indicating a potential deficiency in those suffering from liver complications.
Moreover, we observed a strong inverse relationship between zinc levels and the severity of liver disease, as measured by the Child-Pugh score and the grading of hepatic encephalopathy. This means that as zinc levels dropped, the severity of liver disease increased.
Notably, those with the most severe forms of liver disease also had critical zinc deficiencies. We also highlighted the positive correlation between zinc levels and albumin, suggesting that albumin might play a crucial role in the transport of zinc within the body.
Given these findings, we recommend that monitoring and potentially supplementing zinc in patients with liver cirrhosis could be beneficial, especially for those experiencing complications tied to their liver condition.
Our findings revealed that serum zinc levels were significantly lower in cirrhotic patients compared to healthy controls. In fact, the levels were remarkably diminished, indicating a potential deficiency in those suffering from liver complications.
Moreover, we observed a strong inverse relationship between zinc levels and the severity of liver disease, as measured by the Child-Pugh score and the grading of hepatic encephalopathy. This means that as zinc levels dropped, the severity of liver disease increased.
Notably, those with the most severe forms of liver disease also had critical zinc deficiencies. We also highlighted the positive correlation between zinc levels and albumin, suggesting that albumin might play a crucial role in the transport of zinc within the body.
Given these findings, we recommend that monitoring and potentially supplementing zinc in patients with liver cirrhosis could be beneficial, especially for those experiencing complications tied to their liver condition.
Read More
Most Useful Reviews
1.3
Liver function inflamed
Caution is necessary. I was on supplements like elcysteine and vitamin C for skin blemishes when I added zinc. After taking it, my liver function tests showed concerning results despite a healthy lifestyle. Eventually, I stopped all supplements which improved my liver function. This indicates something may have negatively impacted it, possibly due to the supplements I was taking alongside zinc. Please be cautious if you experience liver function irregularities.
Read More
5.5
Detoxifies liver
I took a high dose of zinc; next time I will reduce it. Zinc plays a role in liver detoxification, protecting it from toxins and aiding their removal.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
- All Researches
9
We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.
To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.
Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).
Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.
To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.
Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).
Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.
Read More
9
We explored how zinc supplementation could help manage cholestatic liver disease, a condition that currently lacks effective treatment options. Our study involved both mice and human participants, revealing interesting changes in gut microbiome dynamics when zinc was introduced. Specifically, we noted that zinc boosts levels of a beneficial bacterium called Blautia producta, which in turn helps produce p-coumaric acid.
The fascinating part is that higher p-coumaric acid levels were linked to reduced liver injury in patients with cholestatic liver disease. In experiments with mice, we found that the protective effects of zinc were partly due to the ability of p-coumaric acid to limit harmful reactive oxygen species in liver cells. This suggests that p-coumaric acid directly supports liver health by preventing cell death and damage.
However, the benefits of zinc were less pronounced when we manipulated the production of p-coumaric acid. This implies that the relationship between zinc, gut bacteria, and liver health is quite intricate. Overall, our findings suggest that zinc may provide valuable support for individuals suffering from cholestatic liver disease, primarily through its influence on the gut microbiome and subsequent metabolic processes.
The fascinating part is that higher p-coumaric acid levels were linked to reduced liver injury in patients with cholestatic liver disease. In experiments with mice, we found that the protective effects of zinc were partly due to the ability of p-coumaric acid to limit harmful reactive oxygen species in liver cells. This suggests that p-coumaric acid directly supports liver health by preventing cell death and damage.
However, the benefits of zinc were less pronounced when we manipulated the production of p-coumaric acid. This implies that the relationship between zinc, gut bacteria, and liver health is quite intricate. Overall, our findings suggest that zinc may provide valuable support for individuals suffering from cholestatic liver disease, primarily through its influence on the gut microbiome and subsequent metabolic processes.
Read More
8
We explored the impact of zinc on liver disease by focusing on its levels in patients with decompensated liver cirrhosis. This study involved 100 individuals with advanced liver issues and another 100 healthy individuals for comparison.
Our findings revealed that serum zinc levels were significantly lower in cirrhotic patients compared to healthy controls. In fact, the levels were remarkably diminished, indicating a potential deficiency in those suffering from liver complications.
Moreover, we observed a strong inverse relationship between zinc levels and the severity of liver disease, as measured by the Child-Pugh score and the grading of hepatic encephalopathy. This means that as zinc levels dropped, the severity of liver disease increased.
Notably, those with the most severe forms of liver disease also had critical zinc deficiencies. We also highlighted the positive correlation between zinc levels and albumin, suggesting that albumin might play a crucial role in the transport of zinc within the body.
Given these findings, we recommend that monitoring and potentially supplementing zinc in patients with liver cirrhosis could be beneficial, especially for those experiencing complications tied to their liver condition.
Our findings revealed that serum zinc levels were significantly lower in cirrhotic patients compared to healthy controls. In fact, the levels were remarkably diminished, indicating a potential deficiency in those suffering from liver complications.
Moreover, we observed a strong inverse relationship between zinc levels and the severity of liver disease, as measured by the Child-Pugh score and the grading of hepatic encephalopathy. This means that as zinc levels dropped, the severity of liver disease increased.
Notably, those with the most severe forms of liver disease also had critical zinc deficiencies. We also highlighted the positive correlation between zinc levels and albumin, suggesting that albumin might play a crucial role in the transport of zinc within the body.
Given these findings, we recommend that monitoring and potentially supplementing zinc in patients with liver cirrhosis could be beneficial, especially for those experiencing complications tied to their liver condition.
Read More
8
Zinc sulfate shows antifibrotic potential
We undertook a study to assess the effects of zinc sulfate on liver fibrosis in patients suffering from chronic Hepatitis C Virus (HCV). In a randomized design, 50 individuals with early-stage fibrosis were split into two groups. One group received standard antiviral therapy, while the other group received the same therapy supplemented with 50 mg of zinc sulfate daily for three months.
Our observations revealed that those in the zinc group experienced notable increases in serum zinc levels. Additionally, markers associated with liver injury, such as fibronectin and hyaluronic acid, showed a significant decline compared to the control group. We also noted that the Aspartate Transaminase-to-Platelet-Ratio Index (APRI), which indicates liver fibrosis, was lower in the zinc group after treatment.
However, there was no significant difference in another liver fibrosis index, the FIB-4 score, between the two groups after the three-month period. This led us to conclude that while zinc sulfate appears to hold promise as a supportive therapy for managing liver fibrosis in chronic HCV patients, more research is needed to fully understand its isolated effects.
Our observations revealed that those in the zinc group experienced notable increases in serum zinc levels. Additionally, markers associated with liver injury, such as fibronectin and hyaluronic acid, showed a significant decline compared to the control group. We also noted that the Aspartate Transaminase-to-Platelet-Ratio Index (APRI), which indicates liver fibrosis, was lower in the zinc group after treatment.
However, there was no significant difference in another liver fibrosis index, the FIB-4 score, between the two groups after the three-month period. This led us to conclude that while zinc sulfate appears to hold promise as a supportive therapy for managing liver fibrosis in chronic HCV patients, more research is needed to fully understand its isolated effects.
Read More
8
We examined the role of zinc treatment in managing Wilson's disease, particularly in a unique case involving a young toddler. Wilson's disease is a genetic disorder that leads to copper buildup in the body, often presenting symptoms in childhood. In the case we observed, the patient underwent various treatments, including zinc acetate after initially experiencing side effects from D-penicillamine.
Zinc treatment is known to help manage copper levels by inhibiting copper absorption in the intestines. In our case study, the toddler responded positively to zinc therapy after discontinuing the first medication. Despite the overall effectiveness of zinc being difficult to isolate since it was used following another drug, it highlights an encouraging alternative for managing Wilson's disease, especially in younger patients.
Additionally, the complexities surrounding zinc's role are underscored by genetic variations that may impact treatment response. This aspect reminds us that each patient's journey with liver disease can differ significantly based on genetic and environmental factors.
Zinc treatment is known to help manage copper levels by inhibiting copper absorption in the intestines. In our case study, the toddler responded positively to zinc therapy after discontinuing the first medication. Despite the overall effectiveness of zinc being difficult to isolate since it was used following another drug, it highlights an encouraging alternative for managing Wilson's disease, especially in younger patients.
Additionally, the complexities surrounding zinc's role are underscored by genetic variations that may impact treatment response. This aspect reminds us that each patient's journey with liver disease can differ significantly based on genetic and environmental factors.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
1.3
Liver function inflamed
Caution is necessary. I was on supplements like elcysteine and vitamin C for skin blemishes when I added zinc. After taking it, my liver function tests showed concerning results despite a healthy lifestyle. Eventually, I stopped all supplements which improved my liver function. This indicates something may have negatively impacted it, possibly due to the supplements I was taking alongside zinc. Please be cautious if you experience liver function irregularities.
Read More
5.5
Detoxifies liver
I took a high dose of zinc; next time I will reduce it. Zinc plays a role in liver detoxification, protecting it from toxins and aiding their removal.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Semeya AA, Elgamal R, Othman AAA. Correlation of Serum Zinc Levels with Hepatic Encephalopathy Severity in Patients with Decompensated Liver Cirrhosis: A Prospective Observational Study from Egypt. Biol Trace Elem Res. 2025. doi:10.1007/s12011-025-04544-x
- Afşar E, Kantar D. How does zinc chelation affect liver sphingolipid metabolism in an Alzheimer's-like model?. J Trace Elem Med Biol. 2025;87:127589. doi:10.1016/j.jtemb.2025.127589
- Amooyi L, Alizadeh L, Sarbakhsh P, Shojaei-Zarghani S, Gharekhani A. The Effects of Adding Probiotic, Alone and in Combination With Zinc, to Routine Treatment on Recurrence of Hepatic Encephalopathy, Quality of Life, and Sleep Quality in Patients With Cirrhosis: An Open-Label Randomized Controlled Trial. Food Sci Nutr. 2025;13:e4636. doi:10.1002/fsn3.4636
- El-Haggar SM, Attalla DS, Elhelbawy M, El-Afify DR. A randomized clinical study to evaluate the possible antifibrotic effect of zinc sulfate in chronic HCV patient receiving direct-acting anti-viral therapy. Inflammopharmacology. 2025;33:329. doi:10.1007/s10787-024-01628-3
- Chim SM, Howell K, Dronzek J, Wu W, Van Hout C, et al. Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings. Elife. 2024;12. doi:10.7554/eLife.90419
- La Rosa A, Covone AE, Coviello D, Arrigo S, Ferro J, et al. Early Onset of Wilson's Disease and Possible Role of Disease-Modifying Genes: A Case Report and Literature Review. Case Reports Hepatol. 2024;2024:3815089. doi:10.1155/crhe/3815089
- Li D, Wan M, Xue L, Zhang Z, Qiu Y, et al. Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury. Cell Host Microbe. 2024;32:2195. doi:10.1016/j.chom.2024.11.002
